Materiomically Designed Polymeric Vehicles for Nucleic Acids: Quo Vadis?
Kumar, R. (2022). Materiomically Designed Polymeric Vehicles for Nucleic Acids: Quo Vadis? ACS Applied Bio Materials. 5, 6, 2507–2535
High-Throughput Experimental Platforms for Polymeric Vector Discovery
Combinatorial Polycation Synthesis and Causal Machine Learning Reveal Divergent Polymer Design Rules for Effective pDNA and Ribonucleoprotein Delivery
Kumar, R., Le, N., Oviedo, F., Brown, M.E., & Reineke, T.M. (2022) Combinatorial Polycation Synthesis and Causal Machine Learning Reveal Divergent Polymer Design Rules for Effective pDNA and Ribonucleoprotein Delivery. JACS Au, 2, 2, 428–442
Facile synthesis of GalNAc monomers and block polycations for hepatocyte gene delivery
Bockman, M.R., Dalal, R.J., Kumar, R., & Reineke, T.M. (2021) Facile synthesis of GalNAc monomers and block polycations for hepatocyte gene delivery. Polymer Chemistry, 10.1039/D1PY00250C.
Cationic Bottlebrush Polymers Outperform Linear Polycation Analogues for pDNA Delivery and Gene Expression
Dalal, R.J., Kumar, R, Ohnsorg, M., Brown, M.E., & Reineke, T.M. (2021) Cationic Bottlebrush Polymers Outperform Linear Polycation Analogues for pDNA Delivery and Gene Expression. ACS Macro Letters, 10, XXX, 886–893.
Polymeric Delivery of Therapeutic Nucleic Acids
Kumar, R*., Chalarca, C.F.S.*, Bockman, M.R.*, Van Bruggen, C., Grimme. C.J., Dalal, R.J., Hanson, M.G., Hexum, J.K., & Reineke, T.M. (2021) Polymeric Delivery of Therapeutic Nucleic Acids. Chemical Reviews, 10.1021/acs.chemrev.0c00997. *equal contribution
Efficient Polymer-Mediated Delivery of Gene- Editing Ribonucleoprotein Payloads through Combinatorial Design, Parallelized Experimentation, and Machine Learning
Kumar, R., Le, N., Tan, Z., Brown, M.E., Jian, S., & Reineke, T.M. (2020) Efficient polymer-mediated delivery of ribonucleoprotein payloads through combinatorial design & parallelized experimentation. ACS Nano, 10.1021/acsnano.0c08549.
Block Polymer Micelles Enable CRISPR/Cas9 Ribonucleoprotein Delivery: Physicochemical Properties Affect Packaging Mechanisms and Gene Editing Efficiency.
Tan, Z., Jiang, Y., Ganewatta, M.S., Kumar, R., Keith, A., Twaroski, K., Pengo, T., Tolar, J., Lodge, T.P., Reineke, T.M. Block Polymer Micelles Enable CRISPR/Cas9 Ribonucleoprotein Delivery: Physicochemical Properties Affect Packaging Mechanisms and Gene Editing Efficiency. Macromolecules, 52, 21, 8197-8206 (2019).