Hydrophobic Monomer Incorporation Tunes the pH Responsivity of Polycationic Brushes

Humpal, A.P., Ofori, P.,  Dhupar, A., Kumar, R.* Hydrophobic Monomer Incorporation Tunes the pH Responsivity of Polycationic Brushes (2026), ACS Macro Letters DOI: 10.1021/acsmacrolett.6c00398

Statistical, Block, and Gradient Copolymers Reveal Microstructure-Dependent Binding and Intracellular Delivery of Genome Editor Proteins

Sekar, R.P.*, Lawson, J.L., Camacho, A.N., Werneth, A., Jordan, K., Paruchuri, A., Kumar, R. *Statistical, Block, and Gradient Copolymers Reveal Microstructure-Dependent Binding and Intracellular Delivery of Genome Editor Proteins (2026), ACS Polymers Au. DOI: 10.1021/acspolymersau.6c00169

Free Polymers Skew Polyplex Solution Properties and Confound the Interpretation of Structure–Function Relationships

Lawson, J.L., Lesco, K.C., Sekar, R.P. , Wheeler, G., Williams, S.K.R., * Kumar, R * Free Polymers Skew Polyplex Solution Properties and Confound the Interpretation of Structure–Function Relationships (2026), ACS Polymers Au,  DOI: 10.1021/acspolymersau.6c00080

Glycosaminoglycan-Inspired Polymer Brushes Promote Human Mesenchymal Stem Cell Proliferation While Retaining Trilineage Differentiation Potential

Nelson, C.L., Castellion, C.A., Humpal, A.P., Sekar, R.P., Chaudhary, N., Villa-Diaz, L.G.*,.,  Kumar, R*. Glycosaminoglycan-Inspired Polymer Brushes Promote Human Mesenchymal Stem Cell Proliferation While Retaining Trilineage Differentiation Potential. (2026), ACS Applied Materials & Interfaces. 10.1021/acsami.5c23781

 

Polymer Microstructure Directs the Solvent-Selective Swelling Response of Polymer Brushes

Humpal, A.P., Dhupar, A., Sekar, R.P., Muyanja, N.S., Chauhan, A.,  Kumar, R*. Polymer Microstructure Directs the Solvent-Selective Swelling Response of Polymer Brushes. (2025), Macromolecules. 10.1021/acs.macromol.5c01659

Tuning DLVO Interactions Alters Polymer-Mediated pDNA Delivery in a Cell Type-Dependent Manner

Sekar, R.P., Lawson, J.L., McGrath, C., Wheeler, G., Moreau, G., Johansen, C.G., Farnsworth, N.L., Kumar, R*. Tuning DLVO Interactions Alters Polymer-Mediated pDNA Delivery in a Cell Type-Dependent Manner. (2025), Langmuir. 10.1021/acs.langmuir.5c00089

The spatial distribution of lipophilic cations in gradient copolymers regulates polymer−pDNA complexation, polyplex aggregation, and intracellular pDNA delivery

Lawson, J.L., Sekar, R.P.,Wright, Wheeler, G., Yanes, J., Estridge, J., Johansen, C.G., Farnsworth, N.L., Kumar, P., Tay, J.W., A.R.E, Kumar, R*. The spatial distribution of lipophilic cations in gradient copolymers regulates polymer−pDNA complexation, polyplex aggregation, and intracellular pDNA delivery, (2024),  Biomacromolecules. 10.1021/acs.biomac.4c01101

Machine learning elucidates design features of pDNA lipid nanoparticles for cell type-preferential transfection

Cheng, L.,  Zhu, Y., Ma, J., Aggarwal, A., Toh, W.H.,  Shin, C., Sangpachatanaruk, W., Weng, G., Kumar, R., * and Mao, H-Q*, Machine learning elucidates design features of pDNA lipid nanoparticles for cell type-preferential transfection, (2024), ACS Nano, 10.1021/acsnano.4c07615

Synergistic Polymer Blending Informs Efficient Terpolymer Design and Machine Learning Discerns Performance Trends for pDNA Delivery

Leyden, M.C., Oviedo, F., Saxena, S., Kumar. R., Le, N., Reineke, T.M., Synergistic Polymer Blending Informs Efficient Terpolymer Design and Machine Learning Discerns Performance Trends for pDNA Delivery, (2024), Bioconjugate Chemistry 

Poly(l-glutamic acid) augments the transfection performance of lipophilic polycations by overcoming tradeoffs among cytotoxicity, pDNA delivery efficiency, and serum stability

Sekar, R.P., Lawson, J.L., Wright, A.R.E, McGrath, C., Schadeck, C., Kumar, P., Tay, J.W., Dragavon, J., Kumar, R*. Poly(l-glutamic acid) augments the transfection performance of lipophilic polycations by overcoming tradeoffs among cytotoxicity, pDNA delivery efficiency, and serum stability (2024), RSC Applied Polymers