The spatial distribution of lipophilic cations in gradient copolymers regulates polymer−pDNA complexation, polyplex aggregation, and intracellular pDNA delivery

Lawson, J.L., Sekar, R.P.,Wright, Wheller, G., Yanes, J., Estridge, J., Johansen, C.G., Farnsowrth, N.L., Kumar, P., Tay, J.W., A.R.E, Kumar, R. The spatial distribution of lipophilic cations in gradient copolymers regulates polymer−pDNA complexation, polyplex aggregation, and intracellular pDNA delivery, (2024),  Biomacromolecules. 10.1021/acs.biomac.4c01101

Machine learning elucidates design features of pDNA lipid nanoparticles for cell type-preferential transfection

Cheng, L.,  Zhu, Y., Ma, J., Aggarwal, A., Toh, W.H.,  Shin, C., Sangpachatanaruk, W., Weng, G., Kumar, R., * and Mao, H-Q*, Machine learning elucidates design features of pDNA lipid nanoparticles for cell type-preferential transfection, (2024), ACS Nano, 10.1021/acsnano.4c07615

Synergistic Polymer Blending Informs Efficient Terpolymer Design and Machine Learning Discerns Performance Trends for pDNA Delivery

Leyden, M.C., Oviedo, F., Saxena, S., Kumar. R., Le, N., Reineke, T.M., Synergistic Polymer Blending Informs Efficient Terpolymer Design and Machine Learning Discerns Performance Trends for pDNA Delivery, (2024), Bioconjugate Chemistry 

Poly(l-glutamic acid) augments the transfection performance of lipophilic polycations by overcoming tradeoffs among cytotoxicity, pDNA delivery efficiency, and serum stability

Sekar, R.P., Lawson, J.L., Wright, A.R.E, McGrath, C., Schadeck, C., Kumar, P., Tay, J.W., Dragavon, J., Kumar, R. Poly(l-glutamic acid) augments the transfection performance of lipophilic polycations by overcoming tradeoffs among cytotoxicity, pDNA delivery efficiency, and serum stability (2024), RSC Applied Polymers

Identification of a novel, MSC-induced macrophage subtype via single-cell sequencing: implications for intervertebral disc degeneration therapy

Koroth, J., Chitwood, C. , Kumar, R., Lin, W-H.,  Reves, B.T., Boyce, T., Reineke, T.M.,  Ellingson, A.M., Johnson, C.P., Stone, L.S., Chaffin, K.C., Simha, N.K., Ogle, B.M., Bradley, E.W.,  Identification of a novel, MSC-induced macrophage subtype via single-cell sequencing: implications for intervertebral disc degeneration therapy   (2024) Front. Cell Dev. Biol,  Volume 11 – 2023

Materiomically Designed Polymeric Vehicles for Nucleic Acids: Quo Vadis?

Kumar, R. (2022). Materiomically Designed Polymeric Vehicles for Nucleic Acids: Quo Vadis? ACS Applied Bio Materials. 5, 6, 2507–2535

Combinatorial Polycation Synthesis and Causal Machine Learning Reveal Divergent Polymer Design Rules for Effective pDNA and Ribonucleoprotein Delivery

Kumar, R., Le, N., Oviedo, F., Brown, M.E., & Reineke, T.M. (2022) Combinatorial Polycation Synthesis and Causal Machine Learning Reveal Divergent Polymer Design Rules for Effective pDNA and Ribonucleoprotein Delivery. JACS Au, 2, 2, 428–442

Facile synthesis of GalNAc monomers and block polycations for hepatocyte gene delivery

Bockman, M.R., Dalal, R.J., Kumar, R., & Reineke, T.M. (2021) Facile synthesis of GalNAc monomers and block polycations for hepatocyte gene delivery. Polymer Chemistry, 10.1039/D1PY00250C.

Cationic Bottlebrush Polymers Outperform Linear Polycation Analogues for pDNA Delivery and Gene Expression

Dalal, R.J., Kumar, R, Ohnsorg, M., Brown, M.E., & Reineke, T.M. (2021) Cationic Bottlebrush Polymers Outperform Linear Polycation Analogues for pDNA Delivery and Gene Expression. ACS Macro Letters, 10, XXX, 886–893.

Polymeric Delivery of Therapeutic Nucleic Acids

Kumar, R*., Chalarca, C.F.S.*, Bockman, M.R.*, Van Bruggen, C., Grimme. C.J., Dalal, R.J., Hanson, M.G., Hexum, J.K., & Reineke, T.M. (2021) Polymeric Delivery of Therapeutic Nucleic Acids. Chemical Reviews, 10.1021/acs.chemrev.0c00997. *equal contribution